Sulfatase modifying factor 1–mediated fibroblast growth factor signaling primes hematopoietic multilineage development
نویسندگان
چکیده
منابع مشابه
Sulfatase modifying factor 1–mediated fibroblast growth factor signaling primes hematopoietic multilineage development
Self-renewal and differentiation of hematopoietic stem cells (HSCs) are balanced by the concerted activities of the fibroblast growth factor (FGF), Wnt, and Notch pathways, which are tuned by enzyme-mediated remodeling of heparan sulfate proteoglycans (HSPGs). Sulfatase modifying factor 1 (SUMF1) activates the Sulf1 and Sulf2 sulfatases that remodel the HSPGs, and is mutated in patients with mu...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2010
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20091022